Continuous Individualized Risk Index (CIRI) (initialism pronounced /ˈsɪri/) is to a set of probabilistic risk models utilizing

Bayesian statistics Bayesian statistics is a theory in the field of statistics based on the Bayesian interpretation of probability where probability expresses a ''degree of belief'' in an event. The degree of belief may be based on prior knowledge about the event, ...

for integrating diverse cancer

biomarkers In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated using blood, urine, or soft tissues to examine normal biological processes, pa ...

over time to produce a unified prediction of outcome risk, as originally described by Kurtz, Esfahani, et al (2019) from Ash Alizadeh’s laboratory at Stanford. Inspired by in game

win probability Win probability is a statistical tool which suggests a sports team's chances of winning at any given point in a game, based on the performance of historical teams in the same situation. The art of estimating win probability involves choosing which p ...

models for predicting winners in sports and political elections, CIRI incorporates serial information obtained throughout a given patient’s course to estimate a personalized estimate of various cancer-related risks over time. CIRI models have been developed available for various cancer types, including

breast cancer Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a r ...

(BRCA),

diffuse large B-cell lymphoma Diffuse large B-cell lymphoma (DLBCL) is a cancer of B cells, a type of lymphocyte that is responsible for producing antibodies. It is the most common form of non-Hodgkin lymphoma among adults, with an annual incidence of 7–8 cases per 100,00 ...

(DLBCL), and chronic lymphocytic leukemia (CLL).The serial information integrated can be diverse, including choice of therapy and the associated responses observed, whether using

liquid biopsies A liquid biopsy, also known as fluid biopsy or fluid phase biopsy, is the sampling and analysis of non-solid biological tissue, primarily blood. Like traditional biopsy, this type of technique is mainly used as a diagnostic and monitoring tool for ...

or radiological studies, pathological and other dynamic measurements.

References

{{reflist Bayesian statistics Prediction